http://localhost:3000 RSS for Node Sat, 30 May 2026 12:01:50 GMT Sat, 30 May 2026 12:01:50 GMT Toxicant exposure has emerged as a global health threat. Toxicant-induced diseases are associated with oxidative stress, inflammation, mitochondrial dysfunction, metabolic dysregulation, and regulated cell death pathways. Toxicants disrupt cellular homeostasis by activating interconnected signaling networks instead of targeting isolated molecular pathways like NF-κB, MAPKs, JAK/STAT, NRF2, HIF-1α, and p53. Recent studies also reveal emerging mechanisms, including ferroptosis, pyroptosis, necroptosis, cGAS-STING signaling, TRPM2-mediated Ca²⁺ dysregulation, ER stress, and SIRT1-dependent pathways that are central to toxicant-induced organ injury. These pathways contribute to various conditions such as neurotoxicity, chronic kidney disease, hepatotoxicity, cardiovascular complications, pulmonary fibrosis, immunotoxicity, and cancer. Additionally, systems biology and network toxicology approaches integrated with omics technologies are facilitating the mapping of dynamic toxicity networks and the identification of novel therapeutic targets. Overall, this review highlights the emerging signaling mechanisms involved in toxicant-related diseases and their potential for biomarker discovery and targeted therapies.

]]> http://localhost:3000/articles/2026.02 cmpdjwj5d01dwk30khh3eu08c Sat, 28 Mar 2026 18:00:00 GMT Lead (Pb) toxicity is one of the largest environmental crises in Bangladesh, significantly impairing plant growth and productivity. Therefore, eco-friendly and cost-effective Pb-toxicity mitigation strategies are highly desirable. The study aimed to explore the potential of Bacillus subtilis in mitigating Pb-toxicity along with plant improvement in Brassica alba L.   In this study, Pb-toxicity significantly inhibited physiological and biochemical traits in B. alba, while the supplantation of B. alba significantly reverted these key physiological and growth attributes. The application of B. subtilis increased plant height by about 26%, shoot biomass by about 18%, root length by about 69%, chlorophyll a by 28.3%, chlorophyll b by 72.2%, total chlorophyll to near-control levels, carotenoids to control-comparable values, and total soluble protein by about 44%.These findings suggest that B. alba is able to actively respond to Pb-stress and that  plays a significant role in enhancing plant growth and Pb-tolerance. This study further indicates that B. subtilis could be a sustainable frontier for ameliorating metal toxicity in crops. These findings together open a paradigm of eco-friendly and cost-effective strategies toward sustainable crop production and global food security.

]]> http://localhost:3000/articles/2026.01 cmonxle5p00ogk30k5b4cv0ev Wed, 25 Mar 2026 18:00:00 GMT Vegetables are essential items of daily commodities. In Bangladesh, vegetable production significantly improved in recent decades due to increased demand for diversity in diet, income generation, and improved demand for vegetable production globally. Unfortunately, the expansion of using chemical pesticides equally dramatic rise in controlling disease and pests during vegetable production. Recent studies indicate that widespread use of pesticide residues (PRs), such as chlorpyrifos, diazinon, malathion, quinalphos, in brinjal (eggplant), tomato, cauliflower, cucumber, guard, and beans. Excessive use of these pesticides crossed the internationally acceptable Maximum Residue Limits (MRLs). The uncontrolled use of these pesticides, combined with other chemical toxicants, limited farmers’ training with low assurance of safety standards, which created a significant food safety crisis in Bangladesh. This study discovers that more than 29% vegetable samples were contaminated with chemical pesticides, and among the contaminated vegetable samples, about 73% crossed the MRLs. The Hazard Quotient (HQ) index value for adolescents and adults in commonly used vegetable eggplant, tomato, and bean indicate non-carcinogenic risks, while multiple PRs are present in single vegetables indicate substantial and significant health hazards.  This study further connects the experiential data from multiple studies across Bangladesh, and focuses on the ways of contamination, significant health risks, limitations in regulatory frameworks, lack of implementation for policy and practice levels. The data presented in the table summarizes residue prevalence and health risk indicators, and two conceptual figures underline the pesticide entry and risk factors. This study recommends sustainable pesticide management, ensuring cost-effective and environmentally friendly agricultural practices at the farmer level, and consumer awareness, which are highly required to ensure sustainable vegetable production, food safety, and public health in Bangladesh.

]]> http://localhost:3000/articles/2025.05 cmkxi50b103mclq0kbv0x5vu5 Sun, 28 Dec 2025 18:00:00 GMT The anti-diabetic effects of Fenugreek seed extract and Vernonia amygdalina leaf extract were studied in alloxan (140 mg/kg)-induced diabetic rats. There were six experimental groups, including A) Control, B) Diabetic, C) Diabetic+Ver (Vernonia, 400 mg/kg), D) Diabetic+Fen (Fenugreek, 200 mg/kg), E) Diabetic+Ver+Fen, and F) Diabetic+Amaryl (10 mg/kg).  After seven weeks, the fasting blood sugar levels, lipid profiles, liver injury, and kidney injury markers were measured. The blood glucose levels of each group of diabetic rats were observed to decrease when administered with Vernonia amygdalina leaf extract, Fenugreek seed extract, and Vernonia with Fenugreek extract. The Vernonia amygdalina leaf extract group had lower mean FBS levels than the Amaryl group, indicating a hypoglycemic effect, and histopathological analysis showed the extract significantly slowed diabetes progression. When compared to a diabetic control rat, treatment with Vernonia and Vernonia combined with Fenugreek improved body weight reduction and dramatically lowered blood glucose levels (P<0.01). The combination of Fenugreek and Vernonia considerably lowers the triglyceride level (P<0.01). The purpose of this study was to assess how Vernonia amygdalina's aqueous leaf extract affected the lipid profile, blood glucose levels, nephropathy, and pancreatic injury of rats with diabetes that had been given alloxan. Data suggest that Vernonia amygdalina leaf compounds may have antidiabetic effects, requiring further study.

]]> http://localhost:3000/articles/2025.04 cmkw2nutg02idlq0kexnfveu0 Sat, 27 Dec 2025 18:00:00 GMT Microplastics (MPs) and nanoplastics are increasingly detected across the food chain, including in fruits and vegetables. While environmental sources (soil, irrigation, air) are well documented, there is growing concern that everyday plastic contact, particularly polybag packaging and wrap used during transport, storage, and sale, can directly deposit MPs on produce or enable migration of additives. This review summarizes current evidence on occurrence, mechanisms by which polybags can contribute to contamination, potential human-health implications of dietary exposure from produce, critical knowledge gaps, and short-term/long-term research and policy priorities. 

]]> http://localhost:3000/articles/2025.03 cmjjhfwc700s2lq0kfrhx9veb Sun, 23 Nov 2025 18:00:00 GMT Dhaka, the capital of Bangladesh, is experiencing a public health emergency due to high air pollution, with emissions of nitrogen dioxide, particulate matter, carbon monoxide, and hydrocarbons from old vehicles. These old vehicles are playing a central role in the deterioration of air quality, and they ultimately cause severe respiratory diseases like asthma, chronic obstructive pulmonary disease, and irritation in all individuals, but especially children and transport workers. Due to old vehicle emissions, the city suffers from excessive levels of harmful pollutants, which surpass WHO and national standards. Thus, immediate steps should be taken to reduce the emissions from old vehicles to protect the population of Dhaka.

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